Quantifying relative virulence: when μ max fails and AUC alone just is not enough
نویسندگان
چکیده
A challenge in virology is quantifying relative virulence ( V R ) between two (or more) viruses that exhibit different replication dynamics a given susceptible host. Host growth curve analysis often used to mathematically characterize virus–host interactions and quantify the magnitude of detriment host due viral infection. Quantifying using canonical parameters, like maximum specific rate μ max ), can fail provide reliable information regarding virulence. Although area-under-the-curve (AUC) calculations are more robust, they sensitive limit selection. Using empirical data from Sulfolobus Spindle-shaped Virus (SSV) infections, we introduce novel, simple metric has proven be robust than existing methods for assessing . This I SC accurately aligns biological phenomena with quantified metrics determine It also addresses gap by permitting comparisons non-lytic virus infections or versus lytic on single-virus/single-host infections.
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The author is John Bascom Professor of Economics and Public Affairs at the University of Wisconsin–Madison. The very helpful comments of Isabel Sawhill and David Ellwood are gratefully acknowledged, as is the discussion of an early draft of the paper by the members of the Brookings Roundtable on Children. A version of this article will be published in 2003 in a volume edited by Isabel Sawhill a...
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ژورنال
عنوان ژورنال: Journal of General Virology
سال: 2021
ISSN: ['1465-2099', '0022-1317']
DOI: https://doi.org/10.1099/jgv.0.001515